Cognitive Engineering

Altered Structural Connectivity Pattern in Schizophrenia

Advances in the development and application of diffusion tensor imaging (DTI) and graph theory methods allow for the investigation of the topological patterns of human white matter networks in vivo. The relationship between neurological functions and synchronized activity of specific and functionalized interconnected brain regions has been widely deliberated in neuroscience studies. It is of great value to the biomedical community to investigate how structural connections between brain regions occur and provide a standardized method to measure and assess these interactions. It has been long proven that structurally segregated and functionally specialized cortical regions of the human cerebral cortex are interconnected by a dense network of cortico-cortical axonal pathways. The disruption of such topological architecture is thought to be present in numerous neuropsychiatric disorders, e.g., Alzheimer's disease, schizophrenia, Parkinson's disease and depression.

The global network hubs with high nodal betweenness in control subjects (NC) and schizophrenia patients (SCZ). A hub region is defined if its nodal betweenness is larger than the sum of the mean and 1 S.D. of all the nodal betweenness. Node betweenness values correspond to node sizes.