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DELGADO Ignacio, MD, PhD

Position

Research Fellow

Education

MD/PhD Max-Plank-Institute for Biophysical Chemistry, Göttingen
MD University of Cantabria, Spain

Neural Prostheses

Ignacio Delgado Martinez, MD-PhD

Ignacio Delgado joined SINAPSE while doing the medical specialization in the department of Neurosurgery of the Charité Universitary Hospital of Berlin (Germany) but his career started as electrophysiologist in the lab of the Nobel prize winner Erwin Neher in Göttingen 10 years ago. Since then he has pursed to bring science to the operation room by gaining a complete education in Neuroscience and Neurosurgery.

The central nervous system (CNS) can be functionally seen as the processing unit of the human body. It processes the different inputs from all the organs producing as a response a complex set of actions. The resulting information is delivered to the output destinations by the peripheral nervous system (PNS). One of the most ambitious goals of science is to understand how the nervous system accomplishes such task. It is known that information processing and transmission in the nervous system is done by specialized neuronal networks using a electrochemical communication. However, there are occasions in which neuronal communication is defective. In this cases, it would be desirable to have a system that would replace the defective networks in order to recover their function. Here is where Neuroprosthetics plays an essential role. By redirecting the nerve signals coming from the brain to an artificial device such a neuroprosthetic implant and delivering the information to the target organs, for example the hand, it is possible to bypass nerve injuries.

In a close future, this very same concept could be used in healthy subjects to improve certain abilities or to enable completely new abilities.

The research from Ignacio will focus in three goals: how can we use the neuroprosthetic technology to:

  • Replace impaired function in the peripheral nervous system (PNS)
  • Enhance the PNS by adding new abilities
  • Assist the PNS with these newly gained abilities

Ignacio's career interests and experience span a wide range of topics from cellular neuroscience to functional neurosurgery. More specifically, the main focus areas of his work have been synaptic transmission and angiogenesis. His work strongly relies on combining different techniques to study physiological function at the cellular level.


Projects

Teaching

  • BN5209 - Neurosensors and Signal Processing
  • BN5104 - Quantitative Physiology Principles in Bioengineering

Publications

Neurovascular coupling: in vivo optical techniques for functional brain imaging. Liao LD, Tsytsarev V, Delgado-Martínez I, Li ML, Erzurumlu R, Vipin A, Orellana J, Lin YR, Lai HY, Chen YY, Thakor NV. Biomed Eng Online. 2013 Apr 30;12:38. doi: 10.1186/1475-925X-12-38.

Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes. Parnis J, Montana V, Delgado-Martinez I, Matyash V, Parpura V, Kettenmann H, Sekler I, Nolte C. J Neurosci. 2013 Apr 24;33(17):7206-19. doi: 10.1523/JNEUROSCI.5721-12.2013.

Differential abilities of SNAP-25 homologs to support neuronal function. Delgado-Martínez I, Nehring RB, Sørensen JB. J Neurosci. 2007 Aug 29;27(35):9380-91.

EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin. Rüder C, Reimer T, Delgado-Martinez I, Hermosilla R, Engelsberg A, Nehring R, Dörken B, Rehm A. Mol Biol Cell. 2005 Mar;16(3):1245-57.