Systems Neurophysiology

Systems Neurophysiology

The Systems Neurophysiology Laboratory conducts in vivo electrophysology experiments in rodents and non-human primates, with the objective to further knowledge of the CNS changes in response to trauma to develop therapies. Here, we study the healthy nervous system to understand the mechanisms and disease models to develop diagnostic and thereapeutic solutions. Our experimental laboratory includes facilities for acute and chronic recordings from individual and populations of neurons of the cortex, spinal cord, and peripheral nerve. In addition, our computational centre includes resources for students and researchers to decode, analyze, and interprent the electrophysiology data which can be correlated with other physiological measurements.

Learning and plasticity of the brain are being studied at the basic level, while disease models of stroke, global ischemic injury, seizures and peripheral neuropathy are underway with the intention of better understanding the pathophysiological mechanisms. Another initiative is to understand the mechanism of thalamo-cortical coupling and hypothermia treatment by developing intracortical recording techniques in animals over extended periods. Tools will include recordings from single neurons to whole brain, using various probes, and advanced imaging such as photoacoustic imaging (nano-neurophotonics).