Contact

Lead Research Scientist Charles Liao
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Neurophotonics

Multimodal Neuroimaging Technology

Our lab uses the novel combination of electrocorticography (ECoG) and functional photoacoustic microscopy (fPAM) (i.e., ECoG-fPAM) to evaluate the functional neurovascular changes pre- and post-ischemia. Several indicators such as somatosensory evoked potential (SSEP), inter-hemispheric coherence, alpha-to-delta ratio (ADR), hemoglobin oxygen saturation (SO2) and cerebral blood volume (CBV) are acquired via the multimodal system to evaluate the changes of neural activity and hemodynamics simultaneously.

Animal models of ischemia

NIL specializes in developing reproducible and minimally invasive rodent models of ischemia which closely mimic the human ischemic condition, based on the photothrombosis technique.

Photothrombotic ischemia model

Photothrombotic ischemia (PTI) model is a minimally invasive, reproducible, and highly focal model of ischemia. Moreover, the PTI model mimics the human ischemic condition and allows us to simultaneously probe the changes in neurovascular function post-ischemia.

Transient ischemic attack model

The transient ischemic attack (TIA) model is a first-of-its kind rodent model of the condition of TIA. It is based on a spontaneously reperfusible photothrombotic ischemia model.

Reperfusible photothrombotic ischemia model

To investigate and better understand the neurovascular changes co-occuring with rtPA thrombolysis, we established a reperfusible PTI model employing rtPA thrombolysis in the developed PTI rodent model of ischemia.